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Table 4 pMSCs modulate expression of genes mediating endothelial cell (EC) permeability and leukocyte infiltration of ECs

From: Human chorionic villous mesenchymal stem/stromal cells protect endothelial cells from injury induced by high level of glucose

Number Gene symbol Gene full name Glucose ΔΔ− 2 value Glucose + CMpMSC ΔΔ− 2 value Fold change, glucose vs glucose + CMpMSC (p < 0.05) Biological activity
1 ALOX5 Arachidonate 5-lipoxygenase 103.45 17.62 53.05-fold ↓ Induces EC permeability
2 ICAM1 Intercellular adhesion molecule 1 11.5 23.85 2.07-fold ↑
3 NPR1 Atrionatriuretic peptide receptor A 1.16 3.79 3.26-fold ↑ Inhibits EC permeability
4 CAV1 Caveolin-1 5.87 3.16 1.85-fold ↓
5 ENG Endoglin 60.47 1.79 33.78-fold ↓ Induces leukocyte infiltration
6 VCAM1 Vascular cell adhesion molecule 1 64.03 1.79 35.77-fold ↓
7 SELL Selectin L 22.05 35.91 1.62-fold ↑
8 SELE E-selectin 22.05 35.91 1.62-fold ↑
  1. CMpMSC conditioned medium of unstimulated pMSCs, pMSC placental mesenchymal stem cell, ↓ decrease, ↑ increase