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Table 6 pMSCs modulate expression of genes mediating endothelial cell (EC) angiogenesis

From: Human chorionic villous mesenchymal stem/stromal cells protect endothelial cells from injury induced by high level of glucose

Number Gene symbol Gene full name Glucose ΔΔ− 2 value Glucose + ICpMSC ΔΔ− 2 value Fold change, glucose vs glucose + ICpMSC (p < 0.05) Biological activity
1 TIMP1 TIMP metallopeptidase inhibitor 1 2.28 6.7 2.93-fold ↑ Inhibits EC angiogenesis
2 CASP1 Apoptosis-related cysteine peptidase 0.01 8.97 897-fold ↑
3 PF4 Platelet factor 4 0.79 3.54 4.48-fold ↑
4 AGT Angiotensinogen 3.3 0.54 6.1-fold ↓
5 COL18A1 Collagen, type XVIII, alpha 1 463 19 24-fold ↓
6 F2R Protease-activated receptor-1 1.8 10.91 6.06-fold ↑ Induces EC angiogenesis
7 ICAM1 Intercellular adhesion molecule 1 11.5 642.79 55.89-fold ↑
8 PGF Placental growth factor 3.21 178.53 55.56-fold ↑
9 CCL2 Monocyte chemotactic protein-1 (MCP-1) 17.72 44.51 2.52-fold ↑
10 PTGS2 Cyclooxygenase (COX) 1.9 3.84 2.02-fold ↑
11 SPHK1 Sphingosine kinase 1 1330.29 1,156,189.43 869-fold ↑ Induces EC migration
12 PF4 Platelet factor 4 0.79 3.54 4.48-fold ↑
13 ICAM1 Intercellular adhesion molecule 1 11.5 642.79 55.89-fold ↑
  1. ICpMSC intercellular direct contact experiment, pMSC placental mesenchymal stem cell, ↓ decrease, ↑ increase