|
Number
|
Gene symbol
|
Gene full name
|
Glucose ΔΔ−2 value
|
Glucose + ICpMSC ΔΔ− 2 value
|
Fold change, glucose compared with glucose + ICpMSC (p < 0.05)
|
Biological activity
|
|---|
|
1
|
ALOX5
|
Arachidonate 5-lipoxygenase
|
103.45
|
0.82
|
126.15-fold ↓
|
Induces EC permeability
|
|
2
|
NPPB
|
Natriuretic peptide B
|
4.12
|
0.04
|
103-fold ↓
|
|
3
|
IL1β
|
Interleukin 1 beta
|
3.37
|
23.52
|
6.97-fold ↑
|
|
4
|
IL6
|
Interleukin 6
|
0.43
|
32.23
|
74.95-fold ↑
|
|
5
|
ICAM1
|
Intercellular adhesion molecule 1
|
11.5
|
642.79
|
55.89-fold ↑
|
|
6
|
CAV1
|
Caveolin-1
|
5.87
|
2.5
|
2.34-fold ↓
|
Inhibits EC permeability
|
|
7
|
NPR1
|
Atrionatriuretic peptide receptor A
|
1.16
|
12.58
|
10.84-fold ↑
|
|
1
|
ENG
|
Endoglin
|
60.47
|
1.89
|
31.99-fold ↓
|
Induces leukocyte infiltration
|
|
2
|
VCAM1
|
Vascular cell adhesion molecule 1
|
64.03
|
1.19
|
53.8-fold ↓
|
|
3
|
SELL
|
Selectin L
|
22.05
|
359.67
|
16.3-fold ↑
|
|
4
|
SELE
|
E-selectin
|
22.05
|
359.67
|
16.31-fold ↑
|
- ICPMSC intercellular direct contact experiment, pMSC placental mesenchymal stem cell, ↓ decrease, ↑ increase
