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Table 7 pMSCs modulate expression of genes mediating endothelial cell (EC) permeability and leukocyte infiltration of ECs

From: Human chorionic villous mesenchymal stem/stromal cells protect endothelial cells from injury induced by high level of glucose

Number Gene symbol Gene full name Glucose ΔΔ−2 value Glucose + ICpMSC ΔΔ− 2 value Fold change, glucose compared with glucose + ICpMSC (p < 0.05) Biological activity
1 ALOX5 Arachidonate 5-lipoxygenase 103.45 0.82 126.15-fold ↓ Induces EC permeability
2 NPPB Natriuretic peptide B 4.12 0.04 103-fold ↓
3 IL1β Interleukin 1 beta 3.37 23.52 6.97-fold ↑
4 IL6 Interleukin 6 0.43 32.23 74.95-fold ↑
5 ICAM1 Intercellular adhesion molecule 1 11.5 642.79 55.89-fold ↑
6 CAV1 Caveolin-1 5.87 2.5 2.34-fold ↓ Inhibits EC permeability
7 NPR1 Atrionatriuretic peptide receptor A 1.16 12.58 10.84-fold ↑
1 ENG Endoglin 60.47 1.89 31.99-fold ↓ Induces leukocyte infiltration
2 VCAM1 Vascular cell adhesion molecule 1 64.03 1.19 53.8-fold ↓
3 SELL Selectin L 22.05 359.67 16.3-fold ↑
4 SELE E-selectin 22.05 359.67 16.31-fold ↑
  1.  ICPMSC intercellular direct contact experiment, pMSC placental mesenchymal stem cell, ↓ decrease, ↑ increase