Fig. 6

Expression level of mRNA of members of the collagen and MMP families in transfected hMSCs. a Heatmap showing the expression of various members of the collagen and MMP families in each group of hMSCs relative to that in nontreated hMSCs. b RT-PCR analysis of COLI, COLII, MMP3, and MMP13 in each group of hMSCs. c Bar graphs of the mRNA levels of COLI, COLII, MMP3, and MMP13. The hMSCs transfected with nothing (panel a), DEX/PEI only (panel b), SOX5-complexed DEX/PEI (panel c), SOX6-complexed DEX/PEI (panel d), SOX9-complexed DEX/PEI (panel e), and SOX5/6/9 (trio) complexed DEX/PEI (DI-NPs) (panel f). n = 5. COL collagen, MMP matrix metallopeptidase