Fig. 5

Effects of TSG-6 knockdown in hAT-MSCs on caerulein and LPS co-induced SAP. a Representative H&E and TUNEL staining images of the pancreatic tissue sections in each group at 200× magnification. TUNEL staining revealed the number of cells undergoing apoptosis or pyroptosis. b The histological scores of H&E and pancreas/body weight ratio were evaluated. c TUNEL-positive cells were counted for each group at 200× magnification. d Collected serum samples were analysed by ELISA for the evaluation of amylase activity, lipase activity, and TNF-α concentration. Results are presented as the mean ± SD. ^*P < 0.05, ^**P < 0.01 (n = 5–8 mice per group). MSC mesenchymal stem cells, PBS phosphate-buffered saline, SAP severe acute pancreatitis, scr scrambled, TSG-6 tumour necrosis factor-α-induced gene/protein 6