Skip to main content


Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: Human cardiac stem cells inhibit lymphocyte proliferation through paracrine mechanisms that correlate with indoleamine 2,3-dioxygenase induction and activity

Fig. 2

Human cardiac/stem progenitor cells (hCSCs) display a favorable immune-suppressive phenotype. Representative expression of the immune relevant molecules indoleamine 2,3-dioxygenase (IDO) and programmed death ligand 1 (PDL-1) after 24 and 48 h in untreated (black line histograms) and interferon (IFN)-γ-activated (red line histograms) cells against isotype controls (gray-filled histograms). The percentages (%) of positive cells are indicated. Human adipose-derived mesenchymal stem cells (hASCs) were used as a positive control for IDO expression. hCSC results are shown for donor hCPC8. Other donors presented similar results

Back to article page