Table 1 Biological, cytogenetic, and molecular characteristics of HD, MDS, and AML patients
Patient ID | Cytogenetics | Molecular | Gender | Age (years) | Risk | MSCs/MNCs | Cytogenetic alteration in MSCs |
|---|---|---|---|---|---|---|---|
AML01 | 46,XX,t(6;9) (p22;q34)[20]a | NPMwt FLT3-ITD | Female | 45 | Highb | 0.97 | ND |
AML02 | 46,XY[20] | ND | Male | 80 | Intermediate | ND | ND |
AML03 | 46,XY[20] | NPMmut FLT3wt | Male | 63 | Low | 1.5 | ND |
AML04 | 46,XY,inv(16) (p13q22)[20] | NPMwt FLT3wt TP53wt | Male | 55 | Low | 0.1 | Negative |
AML05 | 46,XX[20] | NPMmut. FLT3wt TP53wt | Female | 63 | Low | ND | ND |
AML06 c | ND | NPMmut FLT3-ITD TP53wt | Male | 70 | Intermediate | ND | ND |
AML07 | 46,XY,t(15;17) (q22;q22)[20] | ND | Male | 39 | NA | 0.2 | Negative |
AML08 | 46,XX[20] | NPMmut FLT3-ITD/TKD | Female | 47 | Intermediate | 1.3 | ND |
AML09 | 46,XX[20] | NPMmut FLT3-ITD | Female | 61 | Intermediate | 0.7 | ND |
AML10 | 47,XY,+ 8[20] | NPMwt FLT3wt | Male | 68 | Intermediate | ND | ND |
AML11 | 46,XY[20] | NPMmut FLT3-ITD TP53wt | Male | 73 | Intermediate | ND | ND |
AML12 | 47,XY,+der(3) del(3)(p11), t(10;11;19) (p12;q23;q13)[20] | NPMwt FLT3wt | Male | 17 | High | ND | Negative |
AML13 | 44,XX,+der(3) t(3;20)(p12;p11),del(5)(q13q33), −7,–13,t(13;20) (q12;p11), −17,der(21) t(17;21) (q11;q22), +mar[14]/ 45,XX,t(1;16) (q12;q11),del(5) (q13q33),del(6) (q21q25), − 7,add(22)(q13)[6] | NPMwt FLT3wt TP53mut | Female | 60 | High | 0.3 | ND |
AML14 | 46,XX,t(16;16) (p13;q22)[20] | NPMwt. FLT3wt TP53wt | Female | 46 | Low | ND | ND |
AML15 | 46,XY,t(6;11) (q27;q23)[20] | NPMwt FLT3wt TP53wt | Male | 19 | High | 5.6 | ND |
AML16 | 46,XY,inv(16) (p13q22)[18]/ 47,XY,inv(16) (p13q22),+ 22[2] | NPMwt FLT3wt TP53wt | Male | 26 | Low | ND | ND |
AML17 | 46,XX,t(9;11) (p22;q23) [20] | NPMwt FLT3wt | Female | 55 | Intermediate | 0.1 | ND |
AML18 | 47,XX,+X, add(7)(q34)[19]/ 47,XX,+X[1] | ND | Female | 72 | Intermediate | ND | ND |
AML19 | 46,XX[20] | FLT3-ITD | Female | 61 | High | 6.9 | ND |
AML20 | 46,XX[20] | FLT3-ITD | Female | 73 | High | 0.5 | ND |
AML21 | 47,XX,del(5) (q22q33),+ 8[20] | ND | Female | 62 | High | ND | ND |
AML22 | 46,XY[20] | FLT3-ITD | Male | 79 | High | 6.4 | ND |
AML23 | 46,XX[20] | NPMmut FLT3-TKD | Female | 76 | Low | 5.6 | ND |
AML24 | 46,XX,der(4) t(1;4)(q32;q31) [20] | NPMwt FLT3wt TP53wt | Female | 55 | Intermediate | 3.7 | ND |
AML25 | 46,XY[20] | NPMwt FLT3-ITD TP53wt | Male | 31 | Intermediate | ND | ND |
AML26 | ND | NPMwt FLT3wt TP53wt | Male | 57 | NA | 0.5 | ND |
AML27 | ND | NPMmut FLT3wt TP53wt | Male | 59 | Low | ND | ND |
AML28 | 46,XY,–7,+ 21[20] | NPMwt FLT3wt TP53wt | Male | 74 | High | ND | ND |
AML29 | 46,XX[20] | NPMwt FLT3wt TP53wt | Male | 69 | Intermediate | ND | ND |
AML30 | 47,XY,inv(16) (p13q22),+ 8[14]/46,XY,inv.(16) (p13q2)[6] | NPMwt FLT3wt TP53wt | Male | 56 | Low | ND | ND |
AML31 | 46,XY,t(6;9) (p22;q34)[20] | NPMwt FLT3-ITD | Male | 75 | Intermediate | 3.2 | ND |
AML32 | ND | ND | Female | 71 | ND | ND | ND |
MDS1 | 46,XX[20] | Female | 79 | Low/intermediated | 0.8 | ND | |
MDS3 | 46,XY[20] | Male | 62 | Int2/High | ND | ND | |
MDS4 | 46,XY[20] | Male | 78 | Int1/Low | 0.5 | ND | |
MDS5 | 46,XY[20] | Male | 86 | Low/Low | 3.3 | ND | |
MDS6 | 46,XX[20] | Female | 61 | High/High | 2.7 | ND | |
MDS9 | 46,XY[20] | Male | 79 | Low/Low | 1.2 | ND | |
MDS11 | 46,XY,del(20) (q11q13)[20] | Male | 53 | Int1/intermediate | ND | ND | |
MDS12 | 71–74,XXX, +der(2)t(2;17) (p11;p12), del(5)(q13q33), +der(5)del(5) (q13q33), −7[5]/46,XX[5] | Female | 73 | High/high | 6.7 | Negative | |
MDS15 | 46,XX,del(5) (q13q33)[5]/ 46,XX, del(5)(q13q33), del(11)(q21q25) [3] | Female | 76 | Int1/Low | 5.6 | ND | |
MDS16 | 46,XY[20] | Male | 80 | Low/low | 2.6 | ND | |
MDS17 | 46,XY[20] | Male | 68 | High/very high | 6 | ND | |
MDS18 | 46,XY[20] | Male | 66 | Low/low | 8.3 | ND | |
MDS21 | 46,XY[20] | Male | 78 | Low/low | ND | ND | |
MDS22 | 46,XY[30]e | Male | 61 | Low/low | 4.4 | ND | |
MDS24 | 46,XX[20] | Female | 83 | Low/low | 2.5 | ND | |
MDS25 | 46,XX,del(20) (q11q13)[20] | Female | 81 | Low/low | ND | ND | |
MDS26 | 46,XY[20] | Male | 54 | Low/low | 8.9 | ND | |
MDS32 | 46,XX[20] | Female | 67 | Low/low | 2.5 | ND | |
MDS33 | ND | Male | 76 | Int1/high | 3.6 | ND | |
MDS34 | 46,XY[20] | Male | 90 | Int1/low | 3.5 | ND | |
MDS35 | 46,XX[20] | Female | 83 | Low/low | 2.5 | ND | |
MDS36 | 47,XY,+ 8[20] | Male | 82 | Int2/very high | 1.8 | ND | |
MDS38 | 46,X,idic(X) (q13)[16]/45,X, –X[2]/47,X, del(X)(q13), +idic(X)(q13) [1]/47,del(X) (q13),idic(X) (q13) + idic(X) (q13)[1] | Female | 86 | Int1/low | 1.1 | ND | |
MDS39 | 46,XY[20] | Male | 87 | Int1/intermediate | ND | ND | |
MDS43 | 49,XY,+ 1,del(5) (q13q33), +der(5)del(5) (q13q33), + 11[18]/47XY, del(5)(q13q33), +der(5)del(5) (q13q33)[1]/ 46XY,del(5) (q13q33)[1] | Male | 79 | Int2/high | ND | Negative | |
MDS45 | 46,XY,del(13) (q12q14)[3]/ 46,XY[17] | Male | 65 | High/very high | ND | Negative | |
HD01 | 46,XY | – | Male | 22 | – | ND | ND |
HD02 | 46,XY | – | Male | 19 | – | ND | ND |
HD03 | 46,XY | – | Male | 43 | – | 8.4 | ND |
HD04 | 46,XY | – | Male | 44 | – | 2.2 | ND |
HD05 | 46,XY | – | Male | 32 | – | 5.4 | ND |
HD06 | 46,XY | – | Male | 41 | – | 2 | ND |
HD07 | 46,XX | – | Female | 62 | – | 0.5 | ND |
HD08 | 46,XY | – | Male | 60 | – | 14.3 | ND |
HD09 | 46,XX | – | Female | 43 | – | 9.4 | ND |
HD10 | 46,XX | – | Female | 52 | – | 7 | ND |
HD11 | 46,XY | – | Male | 22 | – | 11.2 | ND |
HD12 | 46,XY | – | Male | 38 | – | ND | ND |