Table 3 DBMSCs modulate the expression of genes mediating endothelial cell (EC) angiogenesis and migration. THUVEC (HUVEC were cultured with 100 μM H2O2 for 48 h). TDBMSC (HUVEC were cultured with DBMSC and 100 μM H2O2 for 48 h)
# | Gene symbol | Gene full name | THUVEC mean ΔΔ−2 values | TDBMSC mean ΔΔ−2 values | Fold change (TDBMSC Vs. THUVEC) P < 0.05 | Biological activities |
|---|---|---|---|---|---|---|
1 | CAV1 | Caveolin-1 | 12 | 1472 | > 122-fold ↑ | Inhibit EC angiogenesis |
2 | VWF | von Willebrand Factor | 4 | 693 | > 173-fold ↑ | |
3 | AGT | Angiotensinogen | 1 | 1018 | 1018-fold ↑ | |
4 | CASP3 | Caspases 3 | 24 | 177 | > 7-fold ↑ | |
5 | BAX | Bcl-2-associated X | 4 | 27 | 6.75-fold ↑ | |
6 | F2R | Coagulation Factor II Thrombin Receptor | 20 | 1 | 20-fold ↓ | Induce EC angiogenesis |
7 | FGF1 | Fibroblast Growth Factor 1 | 3384 | 0.12 | 28,200-fold ↓ | |
8 | FGF2 | Fibroblast Growth Factor 2 | 14 | 4 | 3.5-fold ↓ | |
9 | KIT | Tyrosine Protein Kinase Kit or CD117 | 122,521 | 0.74 | > 165568-fold ↓ | |
10 | PTGIS | Prostacyclin Synthase | 7 | 2 | 3.5-fold ↓ | |
11 | PTGS2 | Cyclooxygenase (COX) | 15 | 2 | 7.5-fold ↓ | |
12 | SELPLG | P-selectin glycoprotein ligand-1 | 16 | 4 | 4-fold ↓ | |
13 | TEK | EK Receptor Tyrosine Kinase (TIE-2) | 67 | 20 | 3.35-fold ↓ | |
14 | VEGFA | Vascular Endothelial Growth Factor A | 2919 | 0.52 | > 5613-fold ↓ | |
15 | CFLAR | CASP8 and FADD like apoptosis regulator | 530 | 85 | > 6-fold ↓ | |
16 | EDN1 | Endothelin-1 | 12 | 82 | 6.83-fold ↑ | Induce EC migration |
17 | SPHK1 | Sphingosine Kinase 1 | 44 | 840,958 | 19112.68-fold ↑ | |
18 | HMOX1 | Heme Oxygenase-1 | 7 | 158 | 22.57-fold ↑ |