Table 5 DBMSCs modulate the expression of genes mediating leukocyte infiltration of endothelial cells (EC), adhesion of inflammatory cells and monocyte adhesion and transmigration. THUVEC (HUVEC were cultured with 100 μM H2O2 for 48 h). TDBMSC (HUVEC were cultured with DBMSC and 100 μM H2O2 for 48 h)
# | Gene symbol | Gene full name | THUVEC mean ΔΔ−2 values | TDBMSC mean ΔΔ−2 values | Fold change (TDBMSC Vs. THUVEC) P < 0.05 | Biological activities |
|---|---|---|---|---|---|---|
1 | CDH5 | VE-Cadherin (Vascular Endothelial Cadherin) | 61 | 3 | ~ 20-fold ↓ | Induce leukocyte infiltration |
2 | SELE | E- selectin | 21 | 1 | 21-fold ↓ | |
3 | VCAM1 | Vascular Cell Adhesion Molecule 1 | 7 | 0.26 | 26.92-fold ↓ | |
4 | PLG | Plasminogen | 8 | 90 | ~ 11-fold ↑ | Inhibits adhesion of inflammatory cells |
5 | THBS1 | Thrombospondin 1 (TSP-1) | 1097 | 3 | > 365-fold ↓ | Induces monocyte adhesion and transmigration |