Fig. 4

IL-12 antibodies ameliorated SS-like symptoms in NOD mice partially by regulating T cell responses. a Saliva flow rates of mice on day 7 after treatment with PBS or IL-12 antibody (n = 5 for each group). b Histopathology of submandibular glands determined by HE staining (n = 5 for each group). c–e Percentages and absolute numbers of Th1 (CD4+IFN-γ), Th17 (CD4+IL-17+), and Tfh (CD4+CXCR5+PD-1+) cells in splenocytes of mice (n = 5 for each group). Data are analyzed by unpaired Student t test. Error bars denote ± SD. *p < 0.05, **p < 0.01, ***p < 0.001