Table 1 List of studies on the paracrine and differentiation potential of ASCs for wound repair and regeneration
Topics of the study | Cell source | Isolation method | Animal model | Function | References |
|---|---|---|---|---|---|
Full-thickness cutaneous wound | Inguinal fat pads | Excision | Rat | Epithelial differentiation and secret angiogenic growth factors | [19] |
Acute radiation skin ulcers | Inguinal fat pads | Liposuction | Rat | Promote angiogenesis and granulation | [20] |
Full-thickness excisional ears | Inguinal fat pads | Dissection | Rabbit | Activated fibroblast phenotype, increased macrophage recruitment, and enhanced granulation tissue formation | [21] |
Acute vocal fold wound | Inguinal fat pads | Excision | Canine | Secrete ECM components, particularly elastin | [22] |
Dorsal skin | Human subcutaneous adipose tissue | Excision | Rat | Elevate expression of FGF1 and VEGF | [31] |
Full-thickness dorsal wounds | Human subcutaneous adipose tissue | Cesarean section | Mice | Regulation of ECM molecules and fibroblast differentiation | [32] |
Full-thickness wound | Human subcutaneous adipose tissue | Cesarean section | Mice | Promoting the migration, proliferation of fibroblasts | [33] |
Dorsum circular wound | Human adipose tissue | Liposuction | Mouse | Endothelial and epithelial differentiation | [36] |
Full-thickness excision wound | Human subcutaneous adipose tissue | Liposuction | Mice | Promote angiogenesis, affect epidermal morphogenesis and dermal remodeling | [37] |
Full-thickness wound | Inguinal fat pads | Excision | Mice | Enhance angiogenesis and regenerative cytokine expression | [39] |
Hindlimb ischemia | Human adipose tissue | Liposuction | Mice | Enhanced cell survival and paracrine effects | [40] |
Full-thickness wound | Gonadal adipose tissue | Excision | Rat | Enhance vascularization and reduce scar | [42] |
Full-thickness cutaneous wound | Inguinal fat pads | Excision | Diabetic rat | Enhance angiogenesis and cell proliferation, facilitate regeneration of granulation tissue | [10] |
Full-thickness skin defect wound | Epididymal adipose tissue | Dissection | Zucker diabetic | Improve the survival rate of ASCs | [12] |
Dorsum soft tissue ischemia model | Inguinal fat pads | Excision | Fatty rat Mice | Enhance ASC migration and angiogenesis | [49] |
Non-revascularizable critical limb ischemia patients | Subcutaneous abdominal adipose tissue | Liposuction | Human | Improve trans-cutaneous oxygen pressure and wound ulcers | [50] |