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Fig. 1 | Stem Cell Research & Therapy

Fig. 1

From: Modeling hallmark pathology using motor neurons derived from the family and sporadic amyotrophic lateral sclerosis patient-specific iPS cells

Fig. 1

iPSC generation. a Contrast image of iPSC colonies generated by Sendai virus. Scale bar = 50 μm. b Alkaline phosphatase (AKP) staining of iPSC. c–f Immunofluorescent image of SOX2 (c), NANOG (d), OCT4 (e), and SSEA-4 (f) expression in ALS iPSCs. g–i HE staining of teratoma from ALS iPSCs showing gut epithelia (endoderm), cartilage (mesoderm), and epiderm (ectoderm) like structures. j Karyotyping of iPSCs. (k) DNA sequencing showing heterozygous nucleotides (C/T) in TDP43, but not sporadic and WT iPSCs

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Stem Cell Research & Therapy

ISSN: 1757-6512