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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: Modeling hallmark pathology using motor neurons derived from the family and sporadic amyotrophic lateral sclerosis patient-specific iPS cells

Fig. 5

Mitochondria density decreased on the neurite in ALS MN. a Schematic diagram of conditional expression of NL-EGFP fusion protein in the AAVS1 sites via TALEN. b Phase contrast image of NF inclusion in neurites. Scale bar = 50 μm. c Neurofilament inclusion blocks the mitochondria movement on the neurites. Arrow head indicates colocalization of NF inclusion and mitochondria on neuritis. d Mitotracker staining of mitochondria shows colocalization of NF inclusions and mitochondria in cell body. e, f Mitochondria density decreased in ALS MN, but not in non-MN (*P < 0.05)

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