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Fig. 7 | Stem Cell Research & Therapy

Fig. 7

From: Modeling hallmark pathology using motor neurons derived from the family and sporadic amyotrophic lateral sclerosis patient-specific iPS cells

Fig. 7

ALS MNs are vulnerable to MG132 challenge. a TDP43 translocation in MN after challenge with MG132. Scale bar = 20 μm. b NF inclusion significantly increased in ALS MNs as compared with WT MN but not in non-MNs after challenge with MG132. Scale bar = 50 μm. c Caspase 3-positive cells increased significantly in ALS MNs compared with WT MN but not in non-MNs after challenge with MG132. (*P < 0.05). Scale bar = 50 μm. d LDH concentration increased in ALS MN compared with WT MN but not non-MN after challenge with MG132. (*P < 0.05). e Immunofluorescent images of NF-H and Caspase3 in non-MN cells from TDP43- and EGFP-expressing hESCs after challenge with MG132. Scale bar = 50 μm

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