Fig. 3
From: Influences of donor and host age on human muscle-derived stem cell-mediated bone regeneration
Comparison of bone regeneration mediated by young and old donor LBMP2/GFP-transduced hMDSCs after transplantation in old animal hosts. a MicroCT 3D images of skull defect injury and new bone volume quantification using three different young and old donor hMDSCs. b New bone volume was significantly higher when using old donor 1 cells compared to young donor 1 cells in old animal hosts at 2 and 4 weeks post-injury. c, d No significant difference in new bone volume was found between young donor 2 and old donor 2 cells, nor young donor 3 and old donor 3 cells, in old animal hosts at any time point. e When results for all three old donor cells were combined and compared to combined results for all three young donor cells, significantly more new bone volume was formed by 2 and 4 weeks post-injury when old donor cells were transplanted. *P < 0.05