Fig. 4

Comparison of bone regeneration in young and old animal hosts after transplantation of young donor LBMP2/GFP-transduced hMDSCs. a MicroCT 3D images of skull defect injury and new bone volume quantification using young donor 1–3 cells. b New bone volume was significantly lower in old hosts when compared to young hosts at 2 and 6 weeks post-injury after young donor 1 cells were transplanted. c New bone volume was significantly lower in old hosts when compared to young hosts at 2, 4, and 6 weeks post-injury after using young donor 2 cells. d New bone volume was not significantly different between young and old hosts at any time point when young donor 3 cells were used. e When results for all three old hosts were combined and compared to combined results for all three young hosts, significantly less new bone formation was observed in old hosts at 2 weeks post-injury; differences were not significant at 4 or 6 weeks post-injury. *P < 0.05