Fig. 4

Cancer types most frequently associated with naive AT-/BM-/UC-MSC according to the type of anti-cancer effect produced (suppression or promotion) in vitro and in vivo. a The colored central pie chart depicts the distribution of the four most common tumors upon which naïve MSC were found to have a detrimental (onco-suppressive) effect. The percentage of relative association of each MSC type with each of the tumors is represented by the respective gray-scale peripheral pie chart. The type of MSC most frequently associated with its target tissue and the frequency (%) value are highlighted with a white box within the peripheral pie chart. Total sample size = 54 experiments using solely naïve MSC or naïve MSC as controls for GM-MSC-focused work. Only tumor targets with a minimum sample size of seven (N ≥ 7) are shown. b The colored central pie chart depicts the distribution of the three most common tumors associated with a supportive function (tumor promotion) of MSC. The % relative association of each MSC type with each of the tumors is represented by the respective gray-scale peripheral pie chart. The type of MSC most frequently associated with its target tissue and the frequency (%) value are highlighted with a white box within the peripheral pie chart. Total sample size = 50 experiments using solely naïve MSC in addition to naïve MSC used as controls for GM-MSC-focused work. Only tumor targets with a minimum sample size of seven (N ≥ 7) are shown. In the case of colorectal cancer, the absence of UC from the MSC pie is due to the lack of relevant studies, rather than the lack of tumor promotion on the specific target