Mesenchymal stem cells in preclinical cancer cytotherapy: a systematic review

Table 5 Summary of evidence-based cancer therapy by MSC as deduced by the meta-analysis of peer-reviewed experimental/ preclinical research studies

MSC	MSC GM status #	Tumor target	Effect on tumor target	Evidence in support
AT	Modified (or naïve)	Neural	Suppression	**
UC	Naïve (or modified)	Breast	Suppression	***
UC	Modified (or naïve)	Lung	Suppression	**
BM	Modified	Neural	Suppression	**
BM	Modified	Lung	Suppression	**
BM	Modified (or naïve)	Pancreas	Suppression	*
BM	Naïve	Breast	Promotion	***
BM	Naïve	Osteosarcoma	Promotion	*

# Primary or secondary/minor (in brackets) contribution of the genetic modification status of the MSC to the overall observed effect on tumor target
No. of studies *≥ 3, **≥ 6, ***≥ 10

ISSN: 1757-6512