Table 2 ALT and AST levels and MTHFR mutation analysis in RA patients
Patient | Gender | Hepatotoxicity | MTX treatment | AST (IU/L) | ALT (IU/L) | MTHFR mutation C677T | MTHFR mutation A1298C |
|---|---|---|---|---|---|---|---|
HC1 | Male | No | No | NA | NA | Hetero (C/T) | Hetero (A/C) |
HC2 | Female | No | No | NA | NA | Wild (C/C) | Hetero (A/C) |
HC3 | Female | No | No | NA | NA | NA | NA |
RA1 | Female | Yes | 15 mg/week | 170 | 220 | Homo (T/T) | Wild (A/A) |
RA2 | Male | Yes | 7.5–15 mg/week | 57 | 131 | Wild (C/C) | Wild (A/A) |
RA3 | Male | Yes | 7.5–10 mg/week | 63 | 122 | Hetero (C/T) | Hetero (A/C) |