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Table 2 ALT and AST levels and MTHFR mutation analysis in RA patients

From: Recapitulation of methotrexate hepatotoxicity with induced pluripotent stem cell-derived hepatocytes from patients with rheumatoid arthritis

Patient Gender Hepatotoxicity MTX treatment AST (IU/L) ALT (IU/L) MTHFR mutation
MTHFR mutation
HC1 Male No No NA NA Hetero (C/T) Hetero (A/C)
HC2 Female No No NA NA Wild (C/C) Hetero (A/C)
HC3 Female No No NA NA NA NA
RA1 Female Yes 15 mg/week 170 220 Homo (T/T) Wild (A/A)
RA2 Male Yes 7.5–15 mg/week 57 131 Wild (C/C) Wild (A/A)
RA3 Male Yes 7.5–10 mg/week 63 122 Hetero (C/T) Hetero (A/C)