Predictors of responders to mononuclear stem cell-based therapeutic angiogenesis for no-option critical limb ischemia

Table 3 Univariate and multivariate logistic regression analysis of prognostic factors

Candidate variable	Univariate analysis		Multivariate analysis
Candidate variable	OR(95% CI)	P value	OR (95% CI)	P value
Age ≥ 50 years	0.276 (0.118–0.647)	0.003	0.201 (0.068–0.595)	0.004
Body mass index (kg/m²)	1.032 (0.909–1.172)	0.627
Diabetes mellitus	0.286 (0.053–1.547)	0.146
Hypertension	0.286 (0.053–1.547)	0.146
Hyperlipidemia	3.259 (0.351–30.22)	0.298
Smoker	2.357 (0.831–6.684)	0.107
CRP > 3 mg/L	0.287 (0.117–0.702)	0.006
Fibrinogen > 4 g/L	0.172 (0.064–0.459)	< 0.001	0.176 (0.055–0.563)	0.003
Etiology = ASO	0.296 (0.072–1.218)	0.092
Rutherford class = IV	0.512 (0.151–1.736)	0.283
Gangrene	0.866 (0.396–1.894)	0.718
Arterial occlusion above the knee or elbow*	0.249 (0.104–0.595)	0.002	0.232 (0.077–0.703)	0.010
ABI**	8.345 (1.301–53.54)	0.025
TcPO₂ (mmHg)	1.069 (1.030–1.109)	< 0.001	1.062 (1.017–1.110)	0.006
Using purified CD34⁺ cells	0.913 (0.425–1.961)	0.816
Log (total transplanted CD34+ cell counts)***	2.274 (0.850–6.079)	0.102	3.506 (1.021–12.039)	0.046

*Defined as the highest occlusion level located at common iliac artery, external iliac artery, common femoral artery, superficial femoral artery, popliteal artery, axillary artery, or brachial artery
**ABIs of 99 patients with lower limbs treated were included in this analysis, while the other 4 patients with upper limb lesions were excluded
*** Base-10 logarithm of total transplanted CD34⁺ cell counts
OR, odds ratio; CI, confidential interval; CRP, C-reaction protein; ASO, atherosclerosis obliterans; ABI, ankle-brachial index; TcPO₂: transcutaneous pressure of oxygen; CD, cluster of differentiation

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