Fig. 5
From: Sex influences DNA methylation and gene expression in human skeletal muscle myoblasts and myotubes
Differences in expression and methylation between women and men in both myoblasts and myotubes. a Overlap of number of unique genes with significant differences (q < 0.05) in both gene expression and DNA methylation in myoblasts and myotubes from women versus men. b Gene expression and c DNA methylation in myoblasts and myotubes of CREB5, SYAP1, XIST, ZRSR2 and RPS4X. Only CpG sites with significant differences in DNA methylation in both myoblasts and myotubes are shown. d Genome browser track for ZRSR2 showing the location of the promoter region, CpG sites in the table above, the Refseq gene and histone modifications from ENCODE data in skeletal muscle myoblasts (HSMM). Red line on the chromosome above indicates location on the X-chromosome. N = 11–13, *q < 0.05; H3K4me1, Histone 3 lysine 4 (H3K4) methylation; H3K4me3, H3K4 trimethylation; H3K27ac, H3K27 acetylation; TSS200/TSS1500, 0–200 bp and 200–1500 bp upstream of the transcription start site (TSS), respectively. Data are presented as mean ± SD