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Table 1 Conclusive analysis of matrine, oxymatrine, cytisine, and sophocarpine on contractile, electrophysiological, and structural cardiotoxicity

From: An integrated characterization of contractile, electrophysiological, and structural cardiotoxicity of Sophora tonkinensis Gapnep. in human pluripotent stem cell-derived cardiomyocytes

Compounds Indicators
Functional assessment Structural cardiotoxicity
Base impedance Beat rate Amplitude (IMP) Amplitude (EFP) FPD Cell viability (μM) ROS level (μM) [Ca2+]i (μM) LDH leakage (μM)
Matrine 10 μM (16 h) 2 μM 10 μM (4 h) 50 μM (20 h) 50 μM 50 50 50 2
Oxymatrine 50 μM (8 h) 10 μM (4 h) 50 μM (4 h) 10 μM (12 h) No effect 10 50 50 2
Cytisine 50 μM (12 h) 10 μM 10 μM (4 h) 50 μM (16 h) No effect 50 50 50 2
Sophocarpine 50 μM (8 h) 50 μM (4 h ) 50 μM 50 μM (16 h) 50 μM (0–12 h) 10 10 50 2
  1. The data in the chart was the lowest concentration (and initial time or periods of time) that demonstrated a significant change compare with the control group in these indicators