Table 1 Conclusive analysis of matrine, oxymatrine, cytisine, and sophocarpine on contractile, electrophysiological, and structural cardiotoxicity
Compounds | Indicators | ||||||||
|---|---|---|---|---|---|---|---|---|---|
Functional assessment | Structural cardiotoxicity | ||||||||
Base impedance | Beat rate | Amplitude (IMP) | Amplitude (EFP) | FPD | Cell viability (μM) | ROS level (μM) | [Ca2+]i (μM) | LDH leakage (μM) | |
Matrine | 10 μM (16 h) | 2 μM | 10 μM (4 h) | 50 μM (20 h) | 50 μM | 50 | 50 | 50 | 2 |
Oxymatrine | 50 μM (8 h) | 10 μM (4 h) | 50 μM (4 h) | 10 μM (12 h) | No effect | 10 | 50 | 50 | 2 |
Cytisine | 50 μM (12 h) | 10 μM | 10 μM (4 h) | 50 μM (16 h) | No effect | 50 | 50 | 50 | 2 |
Sophocarpine | 50 μM (8 h) | 50 μM (4 h ) | 50 μM | 50 μM (16 h) | 50 μM (0–12 h) | 10 | 10 | 50 | 2 |