Fig. 2
CCl4-induced liver acute injury was significantly attenuated by iHEPs transplantation in BALB/C nude mouse. a Representative of gross finding of the liver in acute liver injury model by single intra-peritoneal CCl4 injection. A total of 1 × 106 iHEPs (type A) or DMEM only were transplanted through intra-splenic injection. Left to right: olive oil, CCl4, CCl4 + DMEM, and CCl4 + iHEPs group, respectively. b Representative histological finding (H&E staining) of the liver (scale bar, 400 μm). c Serum levels of AST/ALT and hepatic necrosis area in acute liver injury models at indicated time points. Black colored bar indicates intra-splenic DMEM injection only group, gray-colored bar represents intra-splenic iHEPs transplantation group (***P < 0.001, **P < 0.01)