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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: The suppressive effects of miR-508-5p on the odontogenic differentiation of human dental pulp stem cells by targeting glycoprotein non-metastatic melanomal protein B

Fig. 5

GPNMB lacking 3′-UTR can rescue the effect of miR-508-5p. a The expression levels of the odontogenic marker genes (ALP, DMP-1, DSPP, and OCN) were detected by qRT-PCR in each indicated group. b The expression levels of the odontogenic marker genes (ALP, DMP-1, DSPP, and OCN) were detected by Western blotting in each indicated group. c The Western blot results of GPNMB protein were quantified. d On day 7 after the co-transfections of miR-508-5p mimics and GPNMB lacking 3′-UTR of hDPCs, ALP activity increased significantly. e On day 14 after treatment, Alizarin Red S staining was performed to show the effects on the matrix mineralization of hDPCs in each indicated group. *p < 0.05

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Stem Cell Research & Therapy

ISSN: 1757-6512