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Fig. 7 | Stem Cell Research & Therapy

Fig. 7

From: microRNA-690 regulates induced pluripotent stem cells (iPSCs) differentiation into insulin-producing cells by targeting Sox9

Fig. 7

iPSCs-derived IPCs reverse diabetes in vivo. a Image of the entire kidney with iPSCs-derived IPCs engrafted under the kidney capsule and harvested at 25 days post-transplant. (~ 1 × 106 cells/mouse, n = 6 /group). b Blood glucose levels were measured pre- and post-transplantation for over 30 days. c Hematoxylin and eosin (H&E) staining image of iPSCs-derived IPCs grafts in the kidney capsule 25 days after transplantation. Scale bar 200 μm. d Immunofluorescence staining of whole grafts for insulin (red); nuclear DAPI staining is shown in blue. Scale bar 75 μm

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