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Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: The role of the vasculature niche on insulin-producing cells generated by transdifferentiation of adult human liver cells

Fig. 2

Human microvessels promote the survival and function of IPCs in vivo. a The implants retrieved after 4 weeks of implantation were stained using anti-HLA (a, upper panel) and anti-human insulin (a, lower panel) in the IPC/ECFC/MSC implants and the IPC implants. b Quantification of HLA-positive cells was done by counting cells in random five × 40 fields from each implant. Values reported for each experimental condition correspond to the average cell number ± standard error of the mean (SEM) obtained from n > 6 for 4 and 8 weeks, *P value < 0.05. c The IPC/ECFC/MSC implants were double stained for insulin (green) and glucagon (red). d Serum human c-peptide upon glucose stimulation was measured at 2, 4, and 8 weeks post implantation. The results are average and standard error (SE) for three to eight mice per group, at each time point, *P value < 0.05

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