Table 3 SYRCLE risk of bias assessment for the included studies
Author (year) | Random sequence generation? | Groups similar at baseline? | Allocation concealed? | Animals randomly housed? | Blinding of caregivers and/or examiners? | Random selection for outcome assessment? | Blinding of outcome assessor? | Incomplete outcome data addressed? | Free from selective outcome reporting? | Free from other bias? |
|---|---|---|---|---|---|---|---|---|---|---|
Lim et al.(2016) [39] | U | L | U | U | U | U | U | L | L | L |
Lee et al. (2017) [36] | U | L | U | U | U | U | H | L | L | L |
Guo et al.(2013) [30] | U | L | U | U | U | U | U | L | L | L |
Luan et al. (2012) [42] | U | L | U | U | U | U | U | L | L | L |
Baber et al. (2006) [25] | U | L | U | U | U | U | U | L | L | L |
Chen et al. (2014) [27] | U | L | U | U | U | U | U | L | L | L |
Chen et al. (2016) [28] | U | L | U | U | U | U | U | L | L | L |
Cheng et al. (2017) [29] | U | L | U | U | U | U | U | L | L | L |
Huang et al. (2016) [31] | U | L | U | U | U | U | U | L | L | L |
Chen et al. (2016) [26] | U | L | U | U | U | U | U | L | L | L |
Jiang et al. (2012) [32] | U | L | U | U | U | U | U | L | L | L |
Kang et al. (2015) [33] | U | L | U | U | U | U | U | L | L | L |
Lee et al. (2015) [37] | U | L | U | U | U | U | U | L | L | L |
Kim et al. (2012) [34] | U | L | U | U | U | U | U | L | L | L |
Kim et al. (2016) [35] | U | L | U | U | U | U | U | L | L | L |
Liang et al. (2015) [38] | U | L | U | U | U | U | U | L | L | L |
Liu et al. (2015) [40] | U | L | U | U | U | U | U | L | L | L |
Luan et al. (2013) [43] | U | L | U | U | U | U | U | L | L | L |
Luo et al. (2014) [44] | U | L | U | U | U | U | U | L | L | L |
Raoul et al. (2007) [45] | U | L | U | U | U | U | U | L | L | L |
Rathinasabapathy et al. (2016) [46] | U | L | U | U | U | U | U | L | L | L |
Somanna et al. (2014) [47] | U | L | U | U | U | U | U | L | L | L |
Takemiya et al. (2009) [15] | U | L | U | U | U | U | U | L | L | L |
Zhang et al. (2012) [49] | U | L | U | U | U | U | U | L | L | L |
Zhang et al. (2012) [50] | U | L | U | U | U | U | U | L | L | L |
Liu et al. (2011) [41] | U | L | U | U | U | U | U | L | L | L |
Umar et al. (2009) [48] | U | L | U | U | U | U | U | L | L | L |
Kanki et al.(2005) [14] | U | L | U | U | U | U | U | L | L | L |