Fig. 5
From: Differentiation roadmap of embryonic Sertoli cells derived from mouse embryonic stem cells
Differentiation roadmap of generating Sertoli cells. A speculated stepwise derivation process of the mouse Sertoli cell including relevant molecular mechanisms. GATA4 and WT1 promote the generation of coelomic epithelium. SF1 increases the direct precursor cells of eSCs. Sry and Sox9 improve male determination. Dmrt1 maintains the male development of eSCs and suppresses female determination with Sox9