Fig. 7

Distinct expression of human leukocyte antigen (HLA) between hESC-CMs and hiPSC-MSCs. a The expression of HLA class I (HLA-I) and class II (HLA-II) in hiPSC-MSCs (two cell lines) and hESC-CMs (two cell lines) after 1 (i) and 2 days (ii) in the presence or absence of IFN-γ. HLA-II was not expressed in hiPSC-MSCs but weakly expressed in hESC-CMs. Expression of HLA-II was significantly increased in hESC-CMs but not in hiPSC-MSCs after IFN-γ stimulation for 24 h and 48 h (i, ii). b The expression of signal transducer and activator of transcription 1 (P-STAT1) at different time points after IFN-γ stimulation was detected in hESC-CMs (i, ii) and hiPSC-MSCs (iii, iv). c The hiPSC-MSCs exhibited lower levels of P-STAT1 2 days after IFN-γ stimulation compared with hESC-CMs. d The expression of P-STAT1 and HLA-II in hESC-CMs was significantly enhanced in response to IFN-γ stimulation and reduced when cells received fludarabine treatment (*P < 0.05 vs. hESC-CMs using one-way ANOVA with Bonferroni post hoc test)