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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: Exploiting tumor-intrinsic signals to induce mesenchymal stem cell-mediated suicide gene therapy to fight malignant glioma

Fig. 3

hAMSC-SBE4-TRAIL decreased proliferation of GBM in vitro. a Schema showed the collection of co-cultured conditioned media of GBM with commercial hAMSCs, hAMSC-vector, hAMSC-SBE4-TRAIL, or hAMSC-SBE4-TRAIL+TβR inh (control-C-CM, vector-C-CM, SBE4-TRAIL-C-CM, SBE4-TRAIL+TβR inh-C-CM). b–e Flow cytometry of Edu assay showed that the GBM cells (GBM025, GBM079, and GBM106) cultured in SBE4-TRAIL-C-CM had a significant decrease in proliferation compared to those cultured in other groups. f–h MTT assay quantification of GBM025, GBM079, and GBM106 exhibited that these patient-derived GBM cells cultured in SBE4-TRAIL-C-CM displayed a decreased rate of proliferation when compared with those cultured in control-C-CM conditions. Error bars represent SEM. *p < 0.05, **p < 0.01, ***p < 0.001

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Stem Cell Research & Therapy

ISSN: 1757-6512