Skip to main content

Advertisement

Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: The non-homologous end-joining activity is required for Fanconi anemia fetal HSC maintenance

Fig. 4

Inactivation of p53 apoptosis function rescues embryonic lethality and fetal HSC depletion in Fanca−/− DNA-PKcs3A/3A mice. a Deletion of p53 rescues embryonic lethality and fetal HSC depletion in Fanca−/− DNA-PKcs3A/3A mice. Graphical representation of expected vs. observed number of pups based on Mendelian inheritance of alleles. b Deletion of p53 rescues fetal HSC depletion in Fanca−/− DNA-PKcs3A/3A mice. Fetal liver cells from E14.5 embryos with the indicated genotype were subjected to flow cytometric analysis for fetal HSC (CD150+CD48LinMac-1+Sca-1+). ***p < 0.001 vs WT control. c p53515C rescues embryonic lethality in Fanca−/− DNA-PKcs3A/3A mice. Graphical representation of expected vs. observed number of pups based on Mendelian inheritance of alleles. d p53515 rescues fetal HSC depletion in Fanca−/− DNA-PKcs3A/3A mice. Fetal liver cells from E14.5 embryos with the indicated genotype were subjected to flow cytometric analysis for fetal HSC (CD150+CD48LinMac-1+Sca-1+). ***p < 0.001 vs WT control

Back to article page