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Fig. 7 | Stem Cell Research & Therapy

Fig. 7

From: Exosomes derived from umbilical cord mesenchymal stem cells reduce microglia-mediated neuroinflammation in perinatal brain injury

Fig. 7

Prevention of microgliosis by human Wharton’s jelly mesenchymal stem cell-derived exosomes in perinatal brain injury. a Representative chromogenic immunohistochemistry images and quantification of Iba1+ cells in the corpus callosum of healthy rats and of rats 24 h post brain injury with and without exosome treatment. b Representative fluorescent immunohistochemistry images and quantification of CD68+ cells in the corpus callosum of healthy rats and of rats 24 h after brain injury with and without exosome treatment. Bottom row images are higher magnifications (40x) of the top row images (10x). Error bars illustrate mean ± 95% CI of at least three different animals. *p < 0.05, ***p < 0.001, CC corpus callosum, CI confidence interval, CD68 cluster of differentiation 68, DAPI 4′,6-diamidino-2′-phenylindole-dihydrochloride, Exo exosomes, Iba1 ionized calcium-binding adaptor molecule

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