Fig. 1
From: MiR-378a suppresses tenogenic differentiation and tendon repair by targeting at TGF-β2
MiR-378a was inhibited during tenogenic differentiation with TGFβ1 and tendon tissue examination in miR-378 Tg mice. a Sirius Red staining of TDSCs under tenogenic differentiation with TGFβ1 (5 ng/ml) on day 1 and day 7 (n = 3; *p < 0.05 by Student’s t test). b The expression of mir-378a was inhibited during tenogenic differentiation on day 1 and day 7. c H&E and Masson Trichrome staining of tendon tissue in WT and Tg mice (scale bar = 200 μm). d Microstructure of tendon tissue in WT and Tg mice was examined by SEM and TEM (scale bar = 1 μm). e Quantification of diameters of tendon fibrils (n = 4). f Increased interfibrillar space between tendon fibrils in Tg mice compared with that in WT mice (n = 4, *p < 0.05 by Student’s t test)