Fig. 5

Deficiency of ST2 impairs HSC regeneration after irradiation. a Representative FACS analysis of bone marrow c-Kit⁺Sca-1⁺ cells within the Lin⁻ gate (KSL) at day 7 in irradiated WT and ST2-deficient mice. The numbers shown indicate the percentage of c-Kit⁺Sca-1⁺ cells within the Lin⁻population. b Bone marrow KSL cells and CFCs at day 7 in irradiated WT and ST2-deficient mice. Data are mean ± SEM (n = 6 in each group). *P < 0.05 compared to ST2^−/− mice. c The percentage of annexin⁺CD45⁺ cells in the bone marrow at day 7 in irradiated WT and ST2-deficient mice. Data are mean ± SEM (n = 6 in each group). *P < 0.05 compared to ST2^−/− mice. d Numbers of total cells and CFCs at 72 h in irradiated bone marrow Lin⁻c-Kit⁺ cells from WT and ST2-deficient mice. Data are mean ± SEM (n = 3 in each group). *P < 0.05 compared to ST2^−/− TSF