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Fig. 9 | Stem Cell Research & Therapy

Fig. 9

From: microRNA-301b-3p downregulation underlies a novel inhibitory role of long non-coding RNA MBNL1-AS1 in non-small cell lung cancer

Fig. 9

Potential mechanism of lncRNA MBNL1-AS1 involved in the biological activity of NSCLC CSCs via regulation of TGFBR2. In NSCLC CSCs, lncRNA MBNL1-AS1 sponged to miR-301b-3p that negatively regulated TGFBR2, and downregulation of lncRNA MBNL1-AS1 weakened the adsorption capacity, increased miR-301b-3p expression, and reduced TGFBR2 level, thus promoting the proliferation, migration, invasion, drug resistance, and sphere formation yet suppressing the activation of TGF-β pathway. By contrast, lncRNA MBNL1-AS1 overexpression strengthened the adsorption capacity of miR-301b-3p, accompanied by elevated TGFBR2 expression, hence resulting in a decline of the proliferation, migration, invasion, drug resistance, and sphere formation yet an increase in activation of TGF-β pathway

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