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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: Dose-dependent improvement of cardiac function in a swine model of acute myocardial infarction after intracoronary administration of allogeneic heart-derived cells

Fig. 5

Evolution of myocardial damage parameters after pCPC administration in infarcted swine. ac Changes over time in cardiac function parameters as measured with cardiac magnetic resonance (CMR) for the three experimental groups (CON, vehicle; 25 M, receiving 25 × 106 pCPC; 50 M, receiving 50 × 106 pCPC). Treatment effects (defined as the difference between pre-injection and 10-week values). a Changes in left ventricular ejection fraction (LVEF). b End-diastolic volume indexed to body surface area (EDVi). c End-systolic volume indexed to body surface area (ESVi). d Representative CMR and TTC-stained slices from the three studied groups. e Myocardial edema/area at risk (AAR) was calculated as a percentage of the left ventricle in a mid-heart slice using T2-weighted imaging. f Final infarct size (FIS) in an equivalent slice. g Myocardial salvage index (MSI) was then computed as AAR at mid-heart slice minus FIS in an equivalent slice divided by AAR (MSI = (AAR-FIS)/AAR). p values obtained using non-parametric tests (Kruskal-Wallis and Mann-Whitney U tests)

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