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Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: Lineage-specific exosomes promote the odontogenic differentiation of human dental pulp stem cells (DPSCs) through TGFβ1/smads signaling pathway via transfer of microRNAs

Fig. 6

OD-Exo promoted odontogenic differentiation via TGFβ1/smads signaling pathway. a Consistent with pathway analysis, automated western blot analysis found significantly upregulated protein expressions of TGFβ1, TGFR1, p-Smad2/3, and Smad4 in DPSCs treated with OD-Exo, when compared to the control group and UN-Exo-treated group. b In accordance, once we inhibited the TGFβ1 signaling pathways by SB525334, protein levels of p-Smad2/3, DSP, and DMP-1 were significantly reduced in DPSCs treated with OD-Exo

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Stem Cell Research & Therapy

ISSN: 1757-6512