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Fig. 7 | Stem Cell Research & Therapy

Fig. 7

From: Lineage-specific exosomes promote the odontogenic differentiation of human dental pulp stem cells (DPSCs) through TGFβ1/smads signaling pathway via transfer of microRNAs

Fig. 7

Exosomal miR-27a-5p regulated odontogenic differentiation via TGFβ1/smads signaling pathway by downregulating LTBP1. a miR-27a-5p mimics promoted odontogenic differentiation of DPSCs by upregulating the protein expressions of DSP, DMP-1, ALP, and RUNX2. b miR-27a-5p mimics activated TGFβ1/smads signaling pathway by increasing TGFβ1, TGFR1, p-Smad2/3, and Smad4 proteins. c The western blot showed LTBP1 was downregulated bymiR-27a-5p mimics. d The predicted miRNA binding sites in the 3′-UTR of LTBP1. e Luciferase reporter assay found that miR-27a-5p could significantly reduce LTBP1-WT luciferase activity and that miR-27a-5p had no effect on the luciferase activity of LTBP1-MUT group

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Stem Cell Research & Therapy

ISSN: 1757-6512