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Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: miR-34a promotes bone regeneration in irradiated bone defects by enhancing osteoblastic differentiation of mesenchymal stromal cells in rats

Fig. 4

miR-34a regulated the osteoblastic differentiation of irradiated BMSCs by suppressing NOTCH1. qRT-PCR (a) and Western blot (c) analysis of NOTCH1 in irradiated BMSCs after 14 days of osteogenic induction. qRT-PCR (b) and Western blot (d) analysis of NOTCH1 after 14 days of osteogenic induction for BMSCs irradiated with 2 Gy and 4 Gy. qRT-PCR (e) and Western blot (f) analysis of NOTCH1, RUNX2 and OCN in irradiated BMSCs after NOTCH1 knockdown and 14 days of osteogenic induction. Data are shown as mean ± SD, n = 3; *p < 0.05, **p < 0.01, ***p < 0.001

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Stem Cell Research & Therapy

ISSN: 1757-6512