Table 2 Lgr5-mediated tumor suppression in colorectal cancer
Authors | Tumor models | Conclusions | Mechanisms |
|---|---|---|---|
Jang et al. [124] | Colorectal cancer (CRC) samples collected from patients | Lgr5 functions as a tumor suppressor in the late stages of CRC progression | Attenuation of proliferation, migration, and colony formation of colon cancer cells |
Zhou et al. [125] | Human colon carcinoma cell lines (HCT116, RKO, FET, CBS, HCT116b, and TENN) | Lgr5 inhibited cell survival and clonogenic of CRC in vitro; suppression of metastasis of CRC in vivo | R-spondin 1/Lgr5-induced activation of TGF-β signaling with TGF-β type II receptor, inducing inhibition and apoptosis of CRC |
Wu [126] | Primary colorectal tumors from CRC patients; CRC cell lines (HEK293, LS174T, DLD1, HT29, and HCT116) | Inhibition of tumor growth of CRC | RSPO2-induced, Lgr5-dependent Wnt signaling-negative feedback loop |