Fig. 4
FE promotes endothelial cell proliferation, migration and tube formation. a Cell proliferation was assessed using a cell counting kit, and the percentage of optical density values relative to the control was calculated (*p < 0.05). b HUVEC migration was evaluated using a cell migration assay. c The relative percentage of wound healing (24 h) was quantified (*p < 0.05). d Tube formation of HUVECs was performed on solidified Matrigel and stained using Calcein-AM. e The assessment of the number of junctions/mm2 in each group is shown (*p < 0.05). f–h FE was digested with PK or RNase before incubation with HUVECs. f Cell proliferation was assessed using a cell counting kit, and the percentage of optical density values relative to the control was calculated (*p < 0.05). g The relative percentage of wound healing (24 h) was quantified (*p < 0.05). h The assessment of the number of junctions/mm2 in each group is shown (*p < 0.05)