Skip to main content
Fig. 1 | Stem Cell Research & Therapy

Fig. 1

From: Intranasal mesenchymal stem cell secretome administration markedly inhibits alcohol and nicotine self-administration and blocks relapse-intake: mechanism and translational options

Fig. 1

Secretome derived from human adipose tissue-derived MSCs activated with TNF-α and IFN-γ displays an enhanced antioxidant and anti-inflammatory activity. a Secretome derived from non-activated MSCs (light blue bar) shows a lower antioxidant capacity, compared with that of activated MSC-derived secretome (blue bar). Antioxidant capacity of MSC-derived secretome was also compared to the antioxidant capacity of human albumin (gray bar) (one-way ANOVA F2,9 = 92.62, p < 0.0001. Tukey post-hoc: p < 0.001 non-activated MSC secretome versus albumin; p < 0.0001 activated MSC secretome versus albumin and versus non-activated MSC secretome; n = 4 samples per group). b Secretome derived from activated MSCs shows a threefold increase in anti-inflammatory IL-10 and TGF-B1 levels compared with secretome derived from non-activated MSCs (t test; p < 0.05, n = 4 samples per group)

Back to article page

Stem Cell Research & Therapy

ISSN: 1757-6512