Table 1 The top 25 significant GO (biological process) terms associated differentially expressed transcripts at 24 h of hiPSC culture with or without insulin

1

GO_REGULATION_OF_INTRACELLULAR_SIGNAL_TRANSDUCTION

1656

148

0.0894

7.93E−48

3.52E−44

2

GO_TISSUE_DEVELOPMENT

1518

130

0.0856

6.17E−40

1.37E−36

3

GO_CELL_DEVELOPMENT

1426

125

0.0877

2.05E−39

3.03E−36

4

GO_REGULATION_OF_PHOSPHORUS_METABOLIC_PROCESS

1618

133

0.0822

5.80E−39

6.43E−36

5

GO_POSITIVE_REGULATION_OF_RESPONSE_TO_STIMULUS

1929

139

0.0721

1.52E−34

1.35E−31

6

GO_RESPONSE_TO_EXTERNAL_STIMULUS

1821

134

0.0736

3.23E−34

2.39E−31

7

GO_REGULATION_OF_CELL_PROLIFERATION

1496

120

0.0802

4.09E−34

2.59E−31

8

GO_POSITIVE_REGULATION_OF_MULTICELLULAR_ORGANISMAL_PROCESS

1395

115

0.0824

8.90E−34

4.93E−31

9

GO_NEUROGENESIS

1402

115

0.082

1.41E−33

6.93E−31

10

GO_INTRACELLULAR_SIGNAL_TRANSDUCTION

1572

122

0.0776

2.60E−33

1.15E−30

11

GO_POSITIVE_REGULATION_OF_CELL_COMMUNICATION

1532

120

0.0783

3.85E−33

1.55E−30

12

GO_REGULATION_OF_CELL_DEATH

1472

117

0.0795

6.77E−33

2.50E−30

13

GO_REGULATION_OF_MULTICELLULAR_ORGANISMAL_DEVELOPMENT

1672

125

0.0748

1.46E−32

4.98E−30

14

GO_RESPONSE_TO_ENDOGENOUS_STIMULUS

1450

115

0.0793

3.00E−32

9.51E−30

15

GO_CIRCULATORY_SYSTEM_DEVELOPMENT

788

83

0.1053

7.93E−32

2.35E−29

16

GO_PHOSPHATE_CONTAINING_COMPOUND_METABOLIC_PROCESS

1977

135

0.0683

3.57E−31

9.89E−29

17

GO_REGULATION_OF_PROTEIN_MODIFICATION_PROCESS

1710

124

0.0725

4.79E−31

1.25E−28

18

GO_REGULATION_OF_TRANSPORT

1804

127

0.0704

1.44E−30

3.55E−28

19

GO_MOVEMENT_OF_CELL_OR_SUBCELLULAR_COMPONENT

1275

104

0.0816

3.45E−30

8.05E−28

20

GO_POSITIVE_REGULATION_OF_GENE_EXPRESSION

1733

123

0.071

6.25E−30

1.39E−27

21

GO_CELLULAR_RESPONSE_TO_ORGANIC_SUBSTANCE

1848

127

0.0687

1.41E−29

2.98E−27

22

GO_POSITIVE_REGULATION_OF_MOLECULAR_FUNCTION

1791

124

0.0692

3.56E−29

7.18E−27

23

GO_ENZYME_LINKED_RECEPTOR_PROTEIN_SIGNALING_PATHWAY

689

73

0.106

2.96E−28

5.70E−26

24

GO_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND

1381

105

0.076

5.68E−28

1.05E−25

25

GO_REGULATION_OF_CELLULAR_COMPONENT_MOVEMENT

771

76

0.0986

2.37E−27

4.20E−25