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Table 1 The top 25 significant GO (biological process) terms associated differentially expressed transcripts at 24 h of hiPSC culture with or without insulin

From: The role of insulin as a key regulator of seeding, proliferation, and mRNA transcription of human pluripotent stem cells

 GO term# Genes in gene set (K)# Genes in overlap (k)k/Kp valueFDR q value
1GO_REGULATION_OF_INTRACELLULAR_SIGNAL_TRANSDUCTION16561480.08947.93E−483.52E−44
2GO_TISSUE_DEVELOPMENT15181300.08566.17E−401.37E−36
3GO_CELL_DEVELOPMENT14261250.08772.05E−393.03E−36
4GO_REGULATION_OF_PHOSPHORUS_METABOLIC_PROCESS16181330.08225.80E−396.43E−36
5GO_POSITIVE_REGULATION_OF_RESPONSE_TO_STIMULUS19291390.07211.52E−341.35E−31
6GO_RESPONSE_TO_EXTERNAL_STIMULUS18211340.07363.23E−342.39E−31
7GO_REGULATION_OF_CELL_PROLIFERATION14961200.08024.09E−342.59E−31
8GO_POSITIVE_REGULATION_OF_MULTICELLULAR_ORGANISMAL_PROCESS13951150.08248.90E−344.93E−31
9GO_NEUROGENESIS14021150.0821.41E−336.93E−31
10GO_INTRACELLULAR_SIGNAL_TRANSDUCTION15721220.07762.60E−331.15E−30
11GO_POSITIVE_REGULATION_OF_CELL_COMMUNICATION15321200.07833.85E−331.55E−30
12GO_REGULATION_OF_CELL_DEATH14721170.07956.77E−332.50E−30
13GO_REGULATION_OF_MULTICELLULAR_ORGANISMAL_DEVELOPMENT16721250.07481.46E−324.98E−30
14GO_RESPONSE_TO_ENDOGENOUS_STIMULUS14501150.07933.00E−329.51E−30
15GO_CIRCULATORY_SYSTEM_DEVELOPMENT788830.10537.93E−322.35E−29
16GO_PHOSPHATE_CONTAINING_COMPOUND_METABOLIC_PROCESS19771350.06833.57E−319.89E−29
17GO_REGULATION_OF_PROTEIN_MODIFICATION_PROCESS17101240.07254.79E−311.25E−28
18GO_REGULATION_OF_TRANSPORT18041270.07041.44E−303.55E−28
19GO_MOVEMENT_OF_CELL_OR_SUBCELLULAR_COMPONENT12751040.08163.45E−308.05E−28
20GO_POSITIVE_REGULATION_OF_GENE_EXPRESSION17331230.0716.25E−301.39E−27
21GO_CELLULAR_RESPONSE_TO_ORGANIC_SUBSTANCE18481270.06871.41E−292.98E−27
22GO_POSITIVE_REGULATION_OF_MOLECULAR_FUNCTION17911240.06923.56E−297.18E−27
23GO_ENZYME_LINKED_RECEPTOR_PROTEIN_SIGNALING_PATHWAY689730.1062.96E−285.70E−26
24GO_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND13811050.0765.68E−281.05E−25
25GO_REGULATION_OF_CELLULAR_COMPONENT_MOVEMENT771760.09862.37E−274.20E−25