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Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: Combinatorial treatment of acute myocardial infarction using stem cells and their derived exosomes resulted in improved heart performance

Fig. 6

Effects and mechanisms of MSC-derived exosomes and MSC combinatorial therapy on acute myocardial infarction. Delivery of Exo into infarcted hearts 30 min post AMI can significantly reduce inflammatory factors such as IL-6 and TNF-α, increase SDF-1 expression and angiogenesis, and promote cell survival in the stressed ischemic microenvironment at day 3 post AMI. These mechanisms ultimately lead to significant augmentation of cardiac function and reducing scar size of AMI rat hearts after Exo and stem cells combinatorial therapy

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Stem Cell Research & Therapy

ISSN: 1757-6512