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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: Human amniotic mesenchymal stem cells and their paracrine factors promote wound healing by inhibiting heat stress-induced skin cell apoptosis and enhancing their proliferation through activating PI3K/AKT signaling pathway

Fig. 3

hAMSCs and hAMSC-CM inhibited heat stress-induced apoptosis and promoted proliferation of skin cells in vivo. a Estimation of apoptosis in sections from day-7 and day-14 skin tissues of normal, PBS, hAMSCs, H-DMEM, and hAMSC-CM groups by using the TUNEL assay. b Proliferation of skin cells was determined by immunohistochemistry using antibodies against PCNA in sections from day-7 and day-14 skin tissues of the PBS, hAMSCs, H-DMEM, and hAMSC-CM groups. (C) Western blot analysis of PCNA protein levels in day-7 and day-14 skin tissues of the PBS, hAMSCs, H-DMEM, and hAMSC-CM groups. d Representative immunofluorescence images of CK19 expression for re-epithelialization in skin tissues. e Western blot assay for CK19 expression in skin tissues at 7 days and 14 days after treatment

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