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Fig. 7 | Stem Cell Research & Therapy

Fig. 7

From: PBX homeobox 1 enhances hair follicle mesenchymal stem cell proliferation and reprogramming through activation of the AKT/glycogen synthase kinase signaling pathway and suppression of apoptosis

Fig. 7

Inhibition of the AKT/GSK3β signaling pathway activated by the overexpression of PBX1 reduced the generation of iPSCs. a, b Quantification of the number of alkaline phosphatase-positive colonies 32 days after lentivirus vector-mediated transduction by SOMKP with DMSO and LY294002. c SOMKP transduced HF-MSCs cultured with LY294002 were harvested on days 7 (d) and 21 (e) to assess the levels of phospho-AKT, phospho-GSK3β, p16, p21, NANOG, and β-catenin. GAPDH and histone were used as endogenous controls for equal loading. The value in SOMKP-transduced HF-MSCs cultured with DMSO as the control group was set as 1.0. *P < 0.05; **P < 0.01; ***P < 0.001

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Stem Cell Research & Therapy

ISSN: 1757-6512