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Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: Intercellular adhesion molecule-1 enhances the therapeutic effects of MSCs in a dextran sulfate sodium-induced colitis models by promoting MSCs homing to murine colons and spleens

Fig. 6

a, b, c, d ICAM-1-overexpressing MSCs influence the T cell subpopulations in the spleens of IBD mice. The infusion of primary MSCs, C3 cells, C3-vector cells, and C3-ICAM-1 cells downregulates the percentage of Th1 and Th17 cells and upregulates the percentage of Tregs in the spleen in IBD mice. Additionally, ICAM-1-overexpressing MSCs have stronger modulatory effects on repolarization of T cells. No significant changes in Th2 cells were observed in the current study (Fig. 6) (*, P < 0.05)

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Stem Cell Research & Therapy

ISSN: 1757-6512