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Fig. 8 | Stem Cell Research & Therapy

Fig. 8

From: Umbilical cord/placenta-derived mesenchymal stem cells inhibit fibrogenic activation in human intestinal myofibroblasts via inhibition of myocardin-related transcription factor A

Fig. 8

A proposed model showing the mechanism of action of UC/PL-MSCs on TGF-β1-induced fibrogenic activation in human primary intestinal myofibroblasts. TGF-β1 induces expression of Procol1A1, FN, and α-SMA by activating the MRTF-A/SRF signaling and Smad2/3. UC/PL-MSCs inhibit TGF-β1-induced fibrogenic responses by blocking the RhoA/MRTF-A/SRF signaling and Smad2/3

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Stem Cell Research & Therapy

ISSN: 1757-6512