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Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: Restore natural fertility of Kitw/Kitwv mouse with nonobstructive azoospermia through gene editing on SSCs mediated by CRISPR-Cas9

Fig. 6

Natural fertility restoration after repaired SSC transplantation. A Spermatogenesis status of recipient testes 2 months after mutant or repaired SSC transplantation. The germ cells in Kitw/Kitwv SSC recipient testes are positive for spermatogonia marker Lin28a (green) and cannot complete meiosis. In contrast, complete spermatogenesis can be found in recipient testes of repaired SSCs. The distribution pattern of germ cells in Kitw/Kitwv testes and wild type testes were also detected by immunostaining of germ cell marker Tra98 (red) as controls. Scale bar = 50 μm in original size panels and 25 μm in magnified panels. B The offsprings derived from transplanted repaired SSCs

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