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Fig. 1 | Stem Cell Research & Therapy

Fig. 1

From: An overview on small molecule-induced differentiation of mesenchymal stem cells into beta cells for diabetic therapy

Fig. 1

Stages of beta cell differentiation from pluripotent stem cells (PSC) and mesenchymal stem cells. Pluripotent stem cells like ESC/iPSC follow hierarchical targeting of signaling pathways to drive stage-specific genes to generate beta cells. MSC-based protocols do not follow an endoderm differentiation before the endocrine stage. KGF keratinocyte growth factor, T3 tri-iodo thyronine, XXi gamma secretase inhibitor, GLP-1 glucagon-like peptide 1

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Stem Cell Research & Therapy

ISSN: 1757-6512